List of Publications

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2024
Mutations in Tau Protein Promote Aggregation by Favoring Extended Conformations | Kevin Pounot, Clara Piersson, Andrew K. Goring, Frédéric Rosu, Valérie Gabelica, Martin Weik, Songi Han, and Yann Fichou | JACS Au 4 92–100
Molecular Crowding: The History and Development of a Scientific Paradigm | C Alfano, Y Fichou, K Huber, M Weiss, E Spruijt, S Ebbinghaus, ... | Chemical Reviews
2023
Mapping Phase Diagram of Tau-RNA LLPS Under Live Cell Coculturing Conditions. | Lin Y, Fichou Y, Rauch JN, Zhang X, Kosik KS & Han S | Protein Aggregation: Methods and Protocols (Cieplak AS, ed) pp. 269–284. Springer US, New York, NY
Chemical Imaging of RNA-Tau Amyloid Fibrils at the Nanoscale Using Tip-Enhanced Raman Spectroscopy | Cooney GS, Talaga D, Ury-Thiery V, Fichou Y, Huang Y, Lecomte S & Bonhommeau S | Angew Chem Int Ed 62, e202314369
2022
High-resolution Neutron Spectroscopy to Study Picosecond-nanosecond Dynamics of Proteins and Hydration Water | Pounot K, Appel M, Beck C, Weik M, Schirò G, Fichou Y, Seydel T & Schreiber F | JoVE 63664
Total Internal Reflection Tip-Enhanced Raman Spectroscopy of Tau Fibrils | Talaga D, Cooney GS, Ury-Thiery V, Fichou Y, Huang Y, Lecomte S & Bonhommeau S | J. Phys. Chem. B. 126, 5024–5032
Illuminating the Structural Basis of Tau Aggregation by Intramolecular Distance Tracking: A Perspective on Methods. | Zeng Z, Fichou Y, Vigers M, Tsay K & Han S | J. Phys. Chem. B. 126, 6384–6395
2021
Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective | Daskalov A., El Mammeri N., Lends, A., Shenoy J., Lamon G., Fichou Y., Saad A., Martinez D., Morvan E., Berbon M., Grélard A., Kauffmann B., Ferber M., Bardiaux B., Habenstein B., Saupe S. J., Loquet A. | Front. Mol. Neurosci. 14
Diffusive-like motions in a solvent free protein-polymer hybrid | Schirò G.*#, FICHOU*# Y., Brogan A. P. S., Sessions R., Lohstroh W., Zamponi M., Schneider G. J., Gallat F.-X., Paciaroni A., Tobias D. J., Perriman A., Weik M. #. | Phys. Rev. Lett. 126, 088102
Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau. | Lin* Y., FICHOU* Y., Longhini A. P., Llanes L. C., Yin P.; Bazan G. C., Kosik K. S., Han S. | J. Mol. Biol. 433 (2), 166731
2020
Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions | Lin Y., FICHOU Y., Zeng Z., Hu N.Y., Han S. | ACS Neurosci. 11 (4), 615-627
Mechanisms of heparin-induced tau aggregation revealed by single nanopore | Giamblanco* N., FICHOU* Y., Janot J.-M., Balanzat E., Han S., Balme S. | ACS Sensors 5 (4), 1158-1167
2019
Tau-cofactor complexes as building blocks of tau fibrils | Fichou Y., Oberholtzer Z.R., Ngo H., Cheng C.Y., Keller T.J., Eschmann N.A., Han S. | Front. Neurosci. 13
Protein shapes at the core of chronic traumatic encephalopathy | Fichou Y., Han S | Nat. Struct. Mol. Biol. 26, 336–338
The elusive Tau Molecular structures: Can we translate the recent breakthroughs into new targets for intervention? | Fichou Y., Al-Hilaly Y.K., Devred F., Smet-Nocca C., Tsvetkov P.O., Verelst J., Winderickx J., Geukens N., Vanmechelen E., Perrotin A., Serpell L., Hanseeuw B., Medina M., Buée L., Landrieu L. | Neuro Acta Communications 31 (7), 573-575
2018
Cofactors are essential constituents of stable and seeding-active tau fibrils | Fichou*# Y., Lin* Y., Rauch J., Vigers M., Zeng Z., Srivastava M., Keller T., Freed J., Kosic K., Han# S. | Proc. Natl. Acad. Sci. 115(52), 13234–13239
Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer’s disease filaments | Fichou Y., Vigers M., Goring AK., Eschmann NA., Han S. | Chemical Communications 54 (36), 4573-4576
2017
Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium | Barnes R.,Sun S., Fichou Y., Dahlquist F., Heyden M., Han S. | J. Am. Chem. Soc. 139 (49), 17890–17901
Conformation-based assay of Tau protein aggregation. | Fichou Y., Eschmann NA., Keller T., Han S. | Methods Cell Biol. 141, 89–112
2016
A Ring-Shaped Conduit Connects the Mother Cell and Forespore During Sporulation in Bacillus subtilis | Rodrigues C., Henry X., Neumann E., Kurauskas V., Bellard L., Fichou Y., Schanda P., Schoehn G., Rudner D., Morlot C. | Proc. Natl. Acad. Sci. 113, 11585–11590
Mechanisms of Halotolerance: hydration interactions of ectoine with soluble proteins and membranes described by neutron scattering. | Zaccai G., Bagyan I., Combet J., Cuello G., Deme B., Fichou Y., Gallat F.-X., Galvan V., Von Gronau S., Haertlein M., Martel A., Moulin M., Neumann M., Weik M., Oesterhelt D. | Sci. Rep. 6, 31434
2015
Molecular Dynamics Simulations of a Powder Model of the Intrinsically Disordered Protein Tau | Fichou Y., Heyden M., Zaccai G., Weik M., Tobias D. | J. Phys. Chem. B, 119, 12580–12589
Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins | Schirò* G., Fichou* Y., Gallat* F.-X., Wood K., Gabel F., Moulin M., Härtlein M., Heyden M., Colletier J.-P., Orecchini A., Paciaroni A., Wuttke J., Tobias D.J., Weik M. | Nat. Commun. 6, 6490
Hydration water mobility is enhanced around tau amyloid fibers. | Fichou# Y., Schirò G., Gallat F.-X., Laguri C., Moulin M., Combet J., Zamponi M., Härtlein M., Picart C., Mossou E., Lortat-Jacob H., Colletier J.-P., Tobias# D., Weik# M. | Proc. Natl. Acad. Sci. 112, 6365–70
2012
A polymer surfactant corona dynamically replaces water in solvent-free protein liquids and ensures macromolecular flexibility and activity | Gallat* F.-X., Brogan* A.P.S., Fichou Y., McGrath N., Moulin M., Härtlein M., Combet J., Wuttke J., Mann S., Zaccai G., Jackson C.J., Perriman A.W., Weik M | J. Am. Chem. Soc. 134, 13168–13171
Analysis of high-frequency modulation response of strongly injection-locked cascaded semiconductor ring lasers | Smolyakov G.A., Fichou Y., Osinski M. | IEEE J. Quantum Electron. 48, 1568–1577
2011
Synthesis and characterization of core/shell Fe3O4/ZnSe fluorescent magnetic nanoparticles. | Vargas J.M., McBride A.A., Plumley J.B., Fichou Y., Memon T.A., Shah V., Cook,N.C., Akins B.A., Rivera A.C., Smolyakov G.A., O’Brien J.R., Adolphi, N.L., Smyth H.D.C., Osiński M. | J. Appl. Phys. 109, 07B536